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Simultaneous kidney-pancreas transplantation (SKP Tx) is a treatment option for patients with Type I diabetes mellitus and end-stage kidney disease, but acute and chronic rejection remain obstacles to long-term allograft function. This study aimed to determine the role of immune responses to mismatched donor human leukocyte antigen (HLA) and tissue-restricted self-antigens (kidney and pancreas) in...
Immune responses to HLA and tissue-restricted self-antigens (SAgs) have been proposed to play a role in the pathogenesis of renal allograft (KTx) rejection. However, ABO incompatible (ABOi) KTx recipients (KTxR) following depletion of antibodies (Abs) to blood group antigens had fewer rejections. To determine the mechanisms, pre- and post-transplant sera from ABOi (n=18) and ABO-compatible (ABOc)...
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