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New highly efficacious direct-acting antiviral (DAA) therapies are available to treat chronic hepatitis C viral (HCV) infection. Real-world, patient-centered data on harms and benefits associated with these therapies are needed.PROP UP is a multi-center prospective observational study that plans to enroll 1600 patients starting treatment with recently-approved DAA regimens. Informed by extensive input...
Many of the world's peatlands are subject to agricultural runoff, which may impact fundamental biogeochemical processes by altering the concentrations of limiting nutrients. In this study, the distribution of specific microbial genes associated with phosphorus (P) and nitrogen (N) metabolism was compared with potential enzyme activities related to P and N acquisition at five stations along a nutrient...
The interferon-free regimen of simeprevir plus sofosbuvir was recommended by professional guidelines for certain patients with hepatitis C virus (HCV) genotype 1 infection based on the findings of a phase 2 trial. We aimed to evaluate the safety and efficacy of this regimen in clinical practice settings in North America.We collected demographic, clinical, and virologic data, as well as reports of...
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