Search results for: David J. Grignon

Items from 1 to 20 out of 64 results

article

Utility of Pathology Imagebase for standardisation of prostate cancer grading

Lars Egevad, Brett Delahunt, Daniel M Berney, David G Bostwick, more

Aims Despite efforts to standardise grading of prostate cancer, even among experts there is still a considerable variation in grading practices. In this study we describe the use of Pathology Imagebase, a novel reference image library, for setting an international standard in prostate cancer grading. Methods and results The International Society of Urological Pathology (ISUP) recently launched...

article

Renal cell carcinoma with angioleiomyoma-like stroma and clear cell papillary renal cell carcinoma: exploring SDHB protein immunohistochemistry and the relationship to tuberous sclerosis complex

Sean R. Williamson, Jason L. Hornick, John N. Eble, Nilesh S. Gupta, more

Human Pathology > 2018 > 75 > C > 10-15

Renal cell carcinoma (RCC) with angioleiomyoma-like stroma appears to be molecularly distinct from clear cell RCC; however, its relationship to clear cell papillary RCC remains debated. Recent studies have found that similar tumors sometimes occur in patients with tuberous sclerosis complex (TSC), of which 1 study found unexpectedly negative succinate dehydrogenase B (SDHB) immunostaining. We evaluated...

article

Morphological spectrum of renal cell carcinoma, unclassified: an analysis of 136 cases

Carmen M Perrino, David J Grignon, Sean R Williamson, Muhammad T Idrees, more

Histopathology > 72 > 2 > 305 - 319

Aims Renal cell carcinoma, unclassified (RCCU) is a category that includes a morphologically and biologically heterogeneous group of tumours that are unable to be diagnosed as other well‐defined entities. We aim to describe the morphological findings of tumours within this category and to determine the most frequent morphological features leading to classification difficulty. Methods and results...

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Preservation of truncal genomic alterations in clear cell and papillary renal cell carcinomas with sarcomatoid features: An intra‐ and intertumoral, multifocal fluorescence in situ hybridization analysis reveals limited genetic heterogeneity

Joseph M. Sanfrancesco, John N. Eble, David J. Grignon, Mingsheng Wang, more

Molecular Carcinogenesis > 56 > 11 > 2527 - 2537

Understanding tumor genomic heterogeneity may offer vital information in an age of targeted therapy for renal cell carcinoma. We sought to investigate hallmark truncal chromosomal alterations between conventional, sarcomatoid, and matched metastatic tumor foci in clear cell and papillary renal cell carcinomas. A retrospective review identified 58 cases including clear cell (CCRCC) and papillary renal...

article

Testicular cancer: The usage of central review for pathology diagnosis of orchiectomy specimens

Saul E. Harari, Daniel J. Sassoon, David S. Priemer, Joseph M. Jacob, more

Urologic Oncology: Seminars and Original Investigations > 2017 > 35 > 10 > 605.e9-605.e16

Radical orchiectomy specimens present a unique set of challenges for pathology assessment owing to their rarity and complexity. This study compares second opinion pathology reports generated at a single, large academic institution to primary reports from outside hospitals.A database search was conducted for orchiectomy cases that were sent to our institution for management of testicular cancer from...

article

Prognostic Effect of Carcinoma In Situ in Muscle-invasive Urothelial Carcinoma Patients Receiving Neoadjuvant Chemotherapy

Derek E. Thomas, Hristos Z. Kaimakliotis, Kevin R. Rice, Jose A. Pereira, more

Clinical Genitourinary Cancer > 2017 > 15 > 4 > 479-486

Carcinoma in situ (CIS) is a poor prognostic finding in urothelial carcinoma. However, its significance in muscle-invasive urothelial carcinoma (MIUC) treated with neoadjuvant chemotherapy (NAC) is uncertain. We assessed the effect of CIS found in pretreatment transurethral resection of bladder tumor (TURBT) biopsies on the pathologic and clinical outcomes.Subjects with MIUC treated with NAC before...

article

Duration of Androgen Deprivation in Locally Advanced Prostate Cancer: Long-Term Update of NRG Oncology RTOG 9202

Colleen A.F. Lawton, Xiaolei Lin, Gerald E. Hanks, Herbert Lepor, more

International Journal of Radiation Oncology*Biology*Physics > 2017 > 98 > 2 > 296-303

Trial RTOG 9202 was a phase 3 randomized trial designed to determine the optimal duration of androgen deprivation therapy (ADT) when combined with definitive radiation therapy (RT) in the treatment of locally advanced nonmetastatic adenocarcinoma of the prostate. Long-term follow-up results of this study now available are relevant to the management of this disease.Men (N=1554) with adenocarcinoma...

article

Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists

Sean R. Williamson, Ramya Gadde, Kiril Trpkov, Michelle S. Hirsch, more

Human Pathology > 2017 > 63 > C > 149-156

Renal oncocytoma and chromophobe renal cell carcinoma have been long recognized as distinct tumors; however, it remains unknown if uniform diagnostic criteria are used to distinguish these tumor types in practice. A survey was distributed to urologic pathologists regarding oncocytic tumors. Responses were received from 17 of 26 invitees. Histologically, more than 1 mitotic figure was regarded as most...

article

Effect of Long-Term Hormonal Therapy (vs Short-Term Hormonal Therapy): A Secondary Analysis of Intermediate-Risk Prostate Cancer Patients Treated on NRG Oncology RTOG 9202

Amin J. Mirhadi, Qiang Zhang, Gerald E. Hanks, Herbert Lepor, more

International Journal of Radiation Oncology*Biology*Physics > 2017 > 97 > 3 > 511-515

NRG Oncology RTOG 9202 was a randomized trial testing long-term adjuvant androgen deprivation (LTAD) versus initial androgen deprivation only (STAD) with external beam radiation therapy (RT) in mostly high-risk and some intermediate-risk prostate cancer patients. RTOG 9408 found an overall survival (OS) advantage in patients with cT1b-T2b disease and prostate-specific antigen (PSA) <20 ng/mL, with...

article

Evidence of a dual histogenetic pathway of sacrococcygeal teratomas

Robert E Emerson, Chia‐Sui Kao, John N Eble, David J Grignon, more

Histopathology > 70 > 2 > 290 - 300

Aims Sacrococcygeal teratomas are rare tumours that occur most frequently in neonates, although adult cases also occur. The molecular pathogenesis of these tumours and their long‐term prognosis is uncertain. We investigated the i(12p) status of a large number of primary sacrococcygeal teratomas in both children and adults, including cases with malignant germ cell tumour elements. Methods and results...

article

Prostate cancer grading: recent developments and future directions

Brett Delahunt, Lars Egevad, David J Grignon, John R Srigley, more

BJU International > 117 > S4 > 7 - 8

article

Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma

Thu Tran, Carol L Jones, Sean R Williamson, John N Eble, more

Histopathology > 68 > 6 > 850 - 857

AimsSome studies have suggested that tubulocystic carcinoma may be related to papillary renal cell carcinoma. We sought to compare and contrast the molecular and immunohistochemical profiles of tubulocystic carcinoma with those of papillary renal cell carcinoma. Methods and resultsTwelve cases of pure tubulocystic renal cell carcinoma were subjected to fluorescence in‐situ hybridization assessment...

article

Characteristics of the Peritumoral Pseudocapsule Vary Predictably With Histologic Subtype of T1 Renal Neoplasms

Joseph M. Jacob, Sean R. Williamson, Dibson D. Gondim, Joshua A. Leese, more

Urology > 2015 > 86 > 5 > 956-961

To determine characteristics of the peritumoral pseudocapsule (PC) between renal tumor subtypes.The peritumoral PCs of 160 pT1 renal tumors were examined, including 60 clear cell renal cell carcinomas (RCCs), 50 papillary RCCs, 25 chromophobe RCCs, and 25 oncocytoma. Pathologic features (presence or absence of PC, mean thickness, continuity, and invasion by tumor) were analyzed. PC thickness was measured...

article

The application of the Johns Hopkins Hospital Template on urine cytology

Howard H. Wu, Megan Redelman, Shaoxiong Chen, David J. Grignon, more

Diagnostic Cytopathology > 43 > 8 > 593 - 597

BackgroundTo evaluate the utility of the Johns Hopkins Hospital (JHH) template in detection of high‐grade urothelial carcinoma (HGUC). MethodsA computerized search of our laboratory information system was performed for all urine cytology cases from 2009 to 2011 processed by the SurePath™. We included only cases with correlating surgical pathology within 6 months after the urinary samples were obtained...

article

Inflammatory myofibroblastic tumour of the urinary bladder: the role of immunoglobulin G4 and the comparison of two immunohistochemical antibodies and fluorescence in‐situ hybridization for the detection of anaplastic lymphoma kinase alterations

Euna Choi, Sean R Williamson, Rodolfo Montironi, Shaobo Zhang, more

Histopathology > 67 > 1 > 20 - 38

AimsWe examined gene rearrangement and the expression of anaplastic lymphoma kinase (ALK) in urinary bladder inflammatory myofibroblastic tumour (IMT) using fluorescence in‐situ hybridization (FISH) and two immunohistochemical antibodies to ALK. We also investigated whether IMT represents an immunoglobulin (Ig)G4‐related disease. Methods and resultsThe performance of the Dako FLEX ALK monoclonal...

article

Basal cell carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression and overexpression of EGFR

Novae B. Simper, Carol L. Jones, Gregory T. MacLennan, Rodolfo Montironi, more

Human Pathology > 2015 > 46 > 6 > 805-812

Basal cell carcinoma (also referred to as adenoid cystic carcinoma) is a rare tumor of the prostate. Although largely characterized as indolent, poor outcomes have been reported in a considerable fraction of cases. As yet, optimum treatment strategies for this cancer have not been developed. This study investigates protein expression of common or potential molecular therapeutic targets and reports...

article

Clear cell renal cell carcinoma with a syncytial-type multinucleated giant tumor cell component: implications for differential diagnosis

Sean R. Williamson, Jennifer B. Kum, Michael P. Goheen, Liang Cheng, more

Human Pathology > 2014 > 45 > 4 > 735-744

A component of syncytial-type multinucleated tumor giant cells is uncommon in clear cell renal cell carcinoma, and the histogenesis, incidence, and clinical implications of this finding are not well understood. We retrieved 13 such tumors from our pathology archives in patients with a median age of 60years, comprising 1.5% of clear cell renal cell carcinomas. Stage was typically pT4 or pT3 (each 38%)...

article

Cytoplasmic OCT4 staining is a sensitive marker of neuroendocrine differentiation

Riley E. Alexander, Liang Cheng, David J. Grignon, Muhammad T. Idrees

Human Pathology > 2014 > 45 > 1 > 27-32

Previous studies by the authors have described a novel cytoplasmic staining pattern with OCT4 in normal adrenal medullary tissue and in paragangliomas. We aimed to determine if this type of staining is found in other neuroendocrine tissues by examining a broad range of neuroendocrine tumors. Fifty neuroendocrine tumors of various grades and primary organ sites were selected. All cases were immunostained...

article

Cystic partially regressed clear cell renal cell carcinoma: a potential mimic of multilocular cystic renal cell carcinoma

Sean R Williamson, Gregory T MacLennan, Antonio Lopez‐Beltran, Rodolfo Montironi, more

Histopathology > 63 > 6 > 767 - 779

AimsTo study clear cell renal cell carcinomas with predominant cystic and sclerotic components, in which a solid epithelial component precluded a diagnosis of multilocular cystic renal cell carcinoma. We designated these tumours ‘cystic partially regressed clear cell renal cell carcinoma.’ Methods and resultsTwenty‐seven tumours were studied, from patients with a median age of 58 years; the stage...

article

Novel markers of squamous differentiation in the urinary bladder

Wenbin Huang, Sean R. Williamson, Qiu Rao, Antonio Lopez-Beltran, more

Human Pathology > 2013 > 44 > 10 > 1989-1997

Urinary bladder squamous cell carcinoma and urothelial carcinoma with squamous differentiation are often high-grade and high-stage tumors that are thought to be associated with a poorer prognosis and response to therapy compared with urothelial carcinoma without divergent differentiation. Therefore, recognition of a squamous component is increasingly important in guiding prognosis and therapy. We...

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Search results for: David J. Grignon

Utility of Pathology Imagebase for standardisation of prostate cancer grading

Renal cell carcinoma with angioleiomyoma-like stroma and clear cell papillary renal cell carcinoma: exploring SDHB protein immunohistochemistry and the relationship to tuberous sclerosis complex

Morphological spectrum of renal cell carcinoma, unclassified: an analysis of 136 cases

Preservation of truncal genomic alterations in clear cell and papillary renal cell carcinomas with sarcomatoid features: An intra‐ and intertumoral, multifocal fluorescence in situ hybridization analysis reveals limited genetic heterogeneity

Testicular cancer: The usage of central review for pathology diagnosis of orchiectomy specimens

Prognostic Effect of Carcinoma In Situ in Muscle-invasive Urothelial Carcinoma Patients Receiving Neoadjuvant Chemotherapy

Duration of Androgen Deprivation in Locally Advanced Prostate Cancer: Long-Term Update of NRG Oncology RTOG 9202

Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists

Effect of Long-Term Hormonal Therapy (vs Short-Term Hormonal Therapy): A Secondary Analysis of Intermediate-Risk Prostate Cancer Patients Treated on NRG Oncology RTOG 9202

Evidence of a dual histogenetic pathway of sacrococcygeal teratomas

Prostate cancer grading: recent developments and future directions

Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma

Characteristics of the Peritumoral Pseudocapsule Vary Predictably With Histologic Subtype of T1 Renal Neoplasms

The application of the Johns Hopkins Hospital Template on urine cytology

Inflammatory myofibroblastic tumour of the urinary bladder: the role of immunoglobulin G4 and the comparison of two immunohistochemical antibodies and fluorescence in‐situ hybridization for the detection of anaplastic lymphoma kinase alterations

Basal cell carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression and overexpression of EGFR

Clear cell renal cell carcinoma with a syncytial-type multinucleated giant tumor cell component: implications for differential diagnosis

Cytoplasmic OCT4 staining is a sensitive marker of neuroendocrine differentiation

Cystic partially regressed clear cell renal cell carcinoma: a potential mimic of multilocular cystic renal cell carcinoma

Novel markers of squamous differentiation in the urinary bladder

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