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Both 6-substituted aminocarbonyl and acylamino benzimidazole derivatives were designed and synthesized as nonpeptidic angiotensin II AT 1 receptor antagonists. Compounds 6f, 6g, 11e, 11f, 11g, and 12 showed nanomolar AT 1 receptor binding affinity and high AT 1 receptor selectivity over AT 2 receptor in a preliminary pharmacological evaluation. Among them, the two most...
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