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A practical synthesis of (S)-oxybutynin, a muscarinic receptor antagonist, using catalytic enantioselective cyanosilylation of cyclohexyl phenyl ketone (9a) as a key step is described. The key reaction proceeded with 94% ee using 1mol% of Gd-1 catalyst, and was performed on a 100g-scale. In addition, a short catalytic enantioselective synthesis of the versatile intermediate for Scios Nova analogues...
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