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N-methyl-d-aspartate (NMDA) receptor blockade in rodents induces behavioural and neurochemical changes reminiscent of schizophrenia symptoms and pathology. To examine how NMDA receptor blockade affects glutamatergic and GABAergic pathways when administered during early brain development, [ 3 H]MK-801 and [ 3 H]muscimol binding to NMDA and GABA A receptors was examined at four...
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