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In this report we examined the effect of tamoxifen upon the nigrostriatal dopaminergic system. Ovariectomized mice were subjected to one of the following treatments: two subcutaneous injections administered on successive days of the sesame oil vehicle (control), estradiol benzoate (EB-10 μg), tamoxifen citrate (TMX 125 μg) or a combination of EB + TMX. At 24 h after the second injection, the caudate...
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