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Parkinson's disease (PD) is a progressive, neurodegenerative disorder, characterized by hallmark motor symptoms. Deep brain stimulation (DBS) has been used to treat advanced PD successfully. Previous studies have found that the DBS also has an effect on the electrophysiological activity of the deep brain nucleus while alleviate the PD symptoms. Here, in an attempt to gain a greater understanding of...
Parkinson's disease (PD) is a neurodegenerative disorder and severely affects patients' daily lives. The diagnosis depends on the presence of one or more common motor symptoms of the disease. As PD is chronic and slowly progressive, the symptoms continue and worsen over a long period of time. Quantification of the PD's motor symptoms is helpful for diagnosing and monitoring patients' conditions. This...
Objectives: The inaccurate implantation of deep brain stimulation electrode could cause in-effective therapy and varied side-effects. This study aims to intra-operatively localise the subthalamic nucleus (STN) using voluntary movement related local field potentials (LFPs) to improve the electrode implantation accuracy. Methods: STN LFPs were recorded during auditory cued clicking motor task in twelve...
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