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Apoptosis is a distinct mode of cell death that is responsible for the deletion of cells in tumors and in normal tissues. We pursued a pathway‐based approach to investigate the association of potentially functional genetic polymorphisms of the corresponding genes with the outcomes of platinum‐based chemotherapy in advanced non‐small‐cell lung cancer (NSCLC). A MALDI‐TOF mass spectrometer was used...
Genetic polymorphisms in the signalling pathway of estrogen receptor (ER) could modify the risk of breast cancer. A variable number of tandem repeats (VNTR) polymorphism in the promoter of PTTG1IP, pituitary tumor transforming gene binding factor targeted by estrogen receptor α (ERα) in endocrine neoplasia, has been shown to be functional, but its relevance to cancer etiology was unknown. We investigated...
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