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UDP-glucuronosyltransferases (UGTs) catalyze the glucuronidation of a broad spectrum of endobiotic and xenobiotic compounds, which leads to the excretion of hydrophilic glucuronides via bile or urine. By a mechanism of exon sharing, isoforms of the UGT1 family are made from the complex gene locus by an alternative combination of one of the unique first exons with the other commonly used exons. This...
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