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We have previously shown that immunoneutralization of transforming growth factor- (TGF-) in the chick embryo significantly reduces programmed cell death (PCD) in peripheral neurons, spinal cord, and retina. In order to validate these results we have begun to analyze PCD in mice with targeted ablations of the TGF-2 and TGF-3 genes. Recent analyses of mice lacking TGF-3 had failed to reveal an overt...
Abstract. Transforming growth factor-beta (TGF-) is a multifunctional cytokine, whose numerous cell and tissue activities include cell-cycle control, the regulation of early development, differentiation, extracellular matrix formation, hematopoesis, angiogenesis, chemotaxis, immune functions, and the induction of apoptosis. TGF--mediated growth inhibition and apoptosis can be correlated with its function...
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