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The major pathway of γδ cell development is shown to be regulated by in-frame rearrangements at the T cell receptor (TCR) δ locus. Such ''δ selection'' occurs at or around the same point in thymocyte development as selection for in-frame rearrangements at the TCRβ locus. However, there are at least two major differences with β selection: first, δ selection commonly involves selection on the cognate...
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