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Background Somatostatin (SST), a primary inhibitor of gastrin-stimulated gastric acid secretion, has potent antitumor and anti-secretory activity in several human cancers. Aims This study was performed to investigate the SST gene expression levels and possible epigenetic mechanisms that regulate expression of SST in gastric adenocarcinomas. Methods Quantitative real-time (RT)-PCR and quantitative...
BACKGROUND:The checkpoint with forkhead‐associated domain and RING‐finger domain (CHFR) is a mitotic checkpoint protein with tumor‐suppressor functions. In this study, the authors investigated the epigenetic and genetic mechanisms that regulate CHFR expression in esophageal adenocarcinomas (EACs).
METHODS:Quantitative reverse transcriptase polymerase chain reaction analysis demonstrated downregulation...
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