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The 23 full-factorial Central Composite Design (CCD) and response surface methodology (RSM) was applied to explain the effect and interaction of three factors in the process of Fe3O4/SiO2 nanoparticle: NaOH dosage, Fe3O4/SiO2 ratio and Fe2+/Fe3+ ratio. For the CCD optimization purposes, the canonical parameters was employed where the predicted average size of the nanoparticles was 115.39 nm, and the...
A supermagnetic iron oxide (SPIO) microspheres is emerging as an ideal tool for cell tracking and drug targeting delivery. However, its low intracellular labeling efficiency has limited the potential usage. We have developed CdTe-incorporated CMCH/SiO2-coated core-shell composite microspheres, Fe3O4@SiO2@CMCH/CdTe (FSCC), with diameters of 210 nm, as a multifunctional magnetic vector that can efficiently...
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