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The effect of adjusting the pH of a model ovalbumin (iep = 4.7) and aluminum hydroxide adjuvant (iep = 11.5) vaccine or a model lysozyme (iep = 11.4) and aluminum phosphate adjuvant (iep = 5.0) vaccine to values ranging from 3 to 11 was studied. The model vaccine prepared at pH 7.4 served as the reference. Additional adsorption of ovalbumin occurred in the pH range 7.4 to 4.1. Elution of ovalbumin...
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