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This study presents inbred-strain-related differences in tibial bone adaptation response to low-force loading in four-point bending and sham (pad pressure) arrangements in mice. Our previous work in mice has shown that at relatively high but equal bending forces (9 N or a bending moment of 16.88 N-mm), C57BL/6J mice respond with significantly greater bone formation than C3H/HeJ mice. Because of high...
Prostaglandins play an important role in regulating the bone adaptation response to mechanical stimuli. Prostaglandin E2 (PGE 2 ) is an effective modulator of bone metabolism. Administration of PGE 2 to rodents results in increased cancellous and cortical bone mass translating into enhanced mechanical strength. The PGE 2 influence on bone is mediated through four well-characterized...
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