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Natriuretic peptides (NPs) exert their actions through three membrane-bound receptors, which are known as NP receptors (NPRs: NPR-A, NPR-B and NPR-C). In this work we examined the expression of three NPRs in rat retinal ganglion cells (GCs), retrogradely labeled and intracellularly dye-injected, by double immunofluorescence labeling. In vertical sections, almost all GCs, retrogradely labeled by cholera...
Apoptosis plays a key role in normal aging and neurodegeneration. It is now known that normal aging implies low-grade inflammation and increases susceptibility to neurodegenerative diseases, which, in turn, include a neuroinflammatory component. We here investigated, using mice of 2–3 months, 10–11 months, or 18–21 months of age, the expression of apoptosis-regulatory proteins in cortical brain regions...
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