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Various mechanisms are involved in drug hepatotoxicity including reactive intermediates, steatosis, phospholipidosis, mitochondrial dysfunction, etc. Although 3D cultured hepatocytes reflected more CYP 450 mediated reactive intermediates than traditional 2D cultured hepatocytes, the 3D model has not been evaluated for drug-induced phospholipidosis. This study applied 3D cultured hepatocytes in gel...
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