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Objective We previously designed and reported a simple new method (the cold-loaded pain sensation test) for quantitative evaluation of the function of small nerve fibers. In the study reported here, we investigated the clinical usefulness of this test to evaluate diabetic neuropathy by comparison with a device for quantitative measurement of the neuroselective current perception threshold (CPT). ...
We report a 63-year-old obese ketosis-prone diabetic woman who was being treated with metformin and a low dose of insulin. We performed two hyperinsulinemic-euglycemic clamp studies followed by an oral glucose load (clamp-OGL) with and without administration of metformin. These clamp studies revealed that her splanchnic glucose uptake (SGU) was increased from 27.6 to 64.4% by metformin administration,...
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