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Purpose The purpose of the study was to determine how air flow profiles affect fine particle fractions (FPF) (<5 μm) from dry powder aerosol formulations and whether laser diffraction (LD) could be used to measure FPF of aerosols generated by variable flows. Materials and Methods Carrier-based formulations containing 1.5% w/w micronized salbutamol base blended with the 63–90 μm fraction of alpha-lactose...
Purpose The purpose of the study was to determine whether the drug fine particle fraction (FPF) from different dry powder aerosol formulations measured by laser diffraction at a range of flow rates correlated with that measured by inertial impaction. Materials and Methods Ten binary formulations were prepared containing 1.5% w/w salbutamol base or sulphate, blended with the sieved (63–90 μm) fraction...
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