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Background: Eukaryotic initiation factor 5A (elF-5A) contains an unusual amino acid, hypusine [N ε -(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DHS). The modified version of elF-5A, and DHS, are required for eukaryotic cell proliferation. Knowledge of the three-dimensional structure of this...
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