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Summary • Hepcidin is the principal iron-regulatory hormone that controls the absorption of dietary iron and its distribution between stores and extracellular fluid. • Hepcidin acts by binding to the sole known cellular iron efflux channel, ferroportin, and inducing its internalization and degradation, and thereby inhibits the efflux of iron from cells. • Hepcidin synthesis and release...
Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the plasma iron concentrations in humans remain stable at 10–30μM. While most of the iron entering blood plasma comes from recycling, appropriate amount of iron is absorbed from the diet to compensate for losses and maintain nontoxic amounts in stores. Plasma iron concentration and iron distribution are similarly...
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