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To show discriminative power between patients with prostate cancer (PCa) and those with “no evidence of malignancy” using “benign” prostate-specific antigen (bPSA) and the new automated Access benign prostatic hyperplasia-associated (BPHA) research assay within a percent free PSA (%fPSA)-based artificial neural network (ANN) model.The sera from 287 patients with PCa and 254 patients with no evidence...
Different artificial neural networks (ANNs) using total prostate-specific antigen (PSA) and percentage of free PSA (%fPSA) have been introduced to enhance the specificity of prostate cancer detection. The applicability of independently trained ANN and logistic regression (LR) models to different populations regarding the composition (screening versus referred) and different PSA assays has not yet...
To assess the diagnostic performance of the major electrophoretic subforms of free prostate-specific antigen (PSA), named F2 and F3, for differentiating between benign and malignant prostatic disease in men with total PSA (tPSA) concentrations up to 10 μg/L.In sera from 50 patients with prostate cancer (PCa) and 44 men without evidence of malignancy (NPCa), F2 and F3 were quantified by two-dimensional...
Objectives. Cathepsin B, H, and L (CB, CH, CL) are lysosomal proteolytic enzymes that belong to the group of cysteine proteinases. The imbalance between proteinases and their inhibitors is believed to correlate with tumor progression and shortened patient survival. In transitional cell carcinoma (TCC) only limited data have been published.Methods. Using spectrofluorometric assays, catalytic activities...
Objectives. To analyze the excretion of matrix metalloproteinases (MMPs) 2 and 9 in the urine of patients with bladder cancer according to the stage and grade of tumor and to evaluate their diagnostic clinical validity. In numerous carcinomas, increased expression of MMPs is associated with a higher grade of malignancy and poor prognosis.Methods. The study population included 44 controls without evidence...
Objectives. To study quantitatively the relative expression of human glandular kallikrein 2 (hK2) and prostate-specific antigen (PSA) in paired (from the same patient) cancerous and noncancerous prostatic tissue to evaluate whether these proteins are overexpressed or underexpressed in cancer.Methods. We studied 14 patients who underwent radical retropubic prostatectomy for prostate cancer. Cancerous...
Objectives. To investigate the importance of the site of tumor implantation on the treatment response to laser-induced hyperthermia (LIH) of rat prostate cancer (PCa), because interventional manipulations of PCa have been reported to increase metastatic dissemination.Methods. Seven to nine days after either subcutaneous or orthotopic implantation of MatLyLu cells, LIH (46.5 o C) was induced...
Objectives. To study the elimination kinetics of alpha 1 -antichymotrypsin (ACT)-prostate-specific antigen (PSA) and complexed PSA (cPSA) in comparison to the biexponential decrease of total PSA and free PSA after radical prostatectomy.Methods. Serum total PSA, free PSA, ACT-PSA, and cPSA values and the corresponding ratios were determined in venous blood from 12 patients with prostate cancer...
Objectives. To evaluate the analytical performance and diagnostic utility of alpha 1 -antichymotrypsin (ACT)-prostate-specific antigen (PSA) complex in serum to improve the differentiation between benign prostatic hyperplasia (BPH) and prostate cancer (PCa).Methods. Serum concentrations of total PSA (tPSA), free PSA (fPSA), and ACT-PSA were measured in 112 untreated patients with PCa (median...
Objectives. To compare the ability of four commercially available membrane strip tests to detect increased (4 μg/L or more) concentrations of prostate-specific antigen (PSA) in blood.Methods. Serum samples with PSA concentrations less than 4 μg/L (n = 67) and from greater than 4 μg/L to 20 μg/L (n = 32) were independently examined by two observers using the PSA membrane strip tests from Chembio, Medpro,...
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