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IgA is the immunoglobulin subclass responsible for humoral immune protection at mucosal surfaces. However, relatively little is known about the effector functions of the IgA Fc region. We have constructed a panel of hapten-specific human IgA1 mutants and expressed them in baculovirus in order to analyse these functions.We have used these antibodies to examine the binding of IgA to the Fcα receptor...
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