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The tumor suppressor p53 is a transcription factor that is at the center of a network of interactions that affect the cell cycle and apoptosis (Vogelstein et al. 2000; Ryan et al. 2001). The protein is induced by a variety of stresses that include oncogene activation and DNA damage caused by chemotherapy and radiotherapy. On induction, it activates a variety of genes whose products lead to G1 and...
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