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Objective: Tumor necrosis factor alpha (TNFα) is known to mimic ischemic preconditioning (IP). However, it is not known whether TNFα-preconditioning is mediated by 'established' preconditioning signaling or via novel signaling cascades. Moreover, whether TNFα is required to induce the ischemic preconditioning phenotype has not been determined. Methods: To evaluate the role of TNFα, we determined the...
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