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The tumor protein p53‐inducible nuclear protein 2 (TP53INP2) has been reported to participate in autophagy by interacting with autophagosome‐localized autophagy‐related protein 8 (Atg8) family proteins, including LC3. Here, we uncover a novel function for TP53INP2 in the autophagic degradation of proteins. We identify the ubiquitin‐interacting motif (UIM) of TP53INP2 that mediates its binding to ubiquitin...
Acetylation is increasingly recognized as one of the major post-translational mechanisms for the regulation of multiple cellular functions in mammalian cells. Acetyltransferase p300, which acetylates histone and non-histone proteins, has been intensively studied in its role in cell growth and metabolism. However, the mechanism underlying the activation of p300 in cells remains largely unknown. Here,...
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