Search results for: Miao-Lin Hu

Items from 1 to 20 out of 63 results

article

Therapeutic treatment with ascorbate rescues mice from heat stroke-induced death by attenuating systemic inflammatory response and hypothalamic neuronal damage

Chia-Yu Chang, Jen-Yin Chen, Sheng-Hsien Chen, Tain-Junn Cheng, more

Free Radical Biology and Medicine > 2016 > 93 > C > 84-93

The impact of ascorbate on oxidative stress-related diseases is moderate because of its limited oral bioavailability and rapid clearance. However, recent evidence of the clinical benefit of parenteral vitamin C administration has emerged, especially in critical care. Heatstroke is defined as a form of excessive hyperthermia associated with a systemic inflammatory response that results in multiple...

article

The anti-angiogenic action of 2-deoxyglucose involves attenuation of VEGFR2 signaling and MMP-2 expression in HUVECs

I-Chen Chuang, Chih-Min Yang, Tuzz-Ying Song, Nae-Cherng Yang, more

Life Sciences > 2015 > 139 > Complete > 52-61

2-Deoxyglucose (2-DG) is a glucose analogue and has been shown to inhibit angiogenesis in human umbilical vascular endothelial cells (HUVECs) through interference with N-linked glycosylation. However, the anti-angiogenic mechanisms of 2-DG are not fully elucidated.We first employed an ex vivo rat aortic ring model to substantiate the anti-angiogenic action of 2-DG and then used HUVECs to investigate...

article

Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice

Yi-Zhen Liu, Chih-Min Yang, Jen-Yin Chen, Junn-Wang Liao, more

The Journal of Nutritional Biochemistry > 2015 > 26 > 6 > 607-615

This study aimed to investigate the anti-metastatic activity of α-carotene (AC) in Lewis lung carcinoma (LLC) and in combination with taxol in LLC-xenografted C57BL/6 mice. Cell culture studies reveal that AC significantly inhibited invasion, migration and activities of matrix metalloproteinase (MMP)-2, -9 and urokinase plasminogen activator but increased protein expression of tissue inhibitor of...

article

Anti-metastatic effects of antrodan, the Antrodia cinnamomea mycelia glycoprotein, in lung carcinoma cells

Kuan-Ning Fa, Chih-Min Yang, Pei-Chun Chen, Yin-Ying Lee, more

International Journal of Biological Macromolecules > 2015 > 74 > Complete > 476-482

This study investigated the anti-metastatic effects of antrodan, the glycoprotein from Antrodia cinnamomea (AC) mycelia, through direct actions and indirect immunomodulatory effects in Lewis lung carcinoma (LLC). Antrodan was isolated from AC mycelia by alkali extraction, acid precipitation, and purification using sepharose CL-6B column chromatography. In the direct anti-metastatic action, antrodan...

article

A Nampt inhibitor FK866 mimics vitamin B₃ deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD⁺-SIRT1 signaling

Tuzz-Ying Song, Shu-Lan Yeh, Miao-Lin Hu, Mei-Yau Chen, more

Biogerontology > 2015 > 16 > 6 > 789-800

Vitamin B₃ (niacin) deficiency can cause pellagra with symptoms of dermatitis, diarrhea and dementia. However, it is unclear whether the vitamin B₃ deficiency causes human aging. FK866 (a Nampt inhibitor) can reduce intracellular NAD⁺ level and induce senescence of human Hs68 cells. However, the mechanisms underlying FK866-induced senescence of Hs68 cells are unclear. In this study, we used FK866...

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Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD⁺ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells

Nae-Cherng Yang, Tuzz-Ying Song, Yan-Zin Chang, Mei-Yau Chen, more

Biogerontology > 2015 > 16 > 1 > 31-42

Calorie restriction (CR) extends lifespan in a remarkable range of organisms. However, the mechanisms of CR related to the longevity effects are not fully elucidated to date. Using human fibroblast Hs68 (Hs68) cells cultured at a lower level of medium glucose (i.e., glucose restriction; GR) to mimic CR, we investigated the crucial role of nicotinamide phosphoribosyltransferase (Nampt), nicotinamide...

article

Peptic ulcer as a risk factor for postherpetic neuralgia in adult patients with herpes zoster

Jen‐Yin Chen, Kuo‐Mao Lan, Ming‐Jen Sheu, Su‐Feng Tseng, more

Journal of Medical Virology > 87 > 2 > 222 - 229

Postherpetic neuralgia is the most common complication of herpes zoster. Identifying predictors for postherpetic neuralgia may help physicians screen herpes zoster patients at risk of postherpetic neuralgia and undertake preventive strategies. Peptic ulcer has been linked to immunological dysfunctions and malnutrition, both of which are predictors of postherpetic neuralgia. The aim of this retrospective...

article

Suppression of alpha-tocopherol ether-linked acetic acid in VEGF-induced angiogenesis and the possible mechanisms in human umbilical vein endothelial cells

Cheng-Hung Chuang, Chia-Hua Liu, Ta-Jung Lu, Miao-Lin Hu

Toxicology and Applied Pharmacology > 2014 > 281 > 3 > 310-316

Alpha-tocopherol ether-linked acetic acid (α-TEA) has been reported to exhibit both anti-tumor and anti-metastatic activities in cell culture and animal studies. However, it is unclear whether α-TEA possesses anti-angiogenic effects. In this study, we investigated the effect of α-TEA on vascular endothelial growth factor (VEGF)-induced angiogenesis and matrix metalloproteinase (MMP) expression both...

article

Fatal tumor lysis syndrome in a patient with metastatic colon cancer after palliative chemotherapy

Ming-Hao Hsieh, Chou-Chan Chen, Miao-Lin Hu, Te-Cheng Yueh

Formosan Journal of Surgery > 2013 > 46 > 6 > 200-203

Tumor lysis syndrome (TLS) is a rare but life-threatening complication of chemotherapy in patients with solid tumors such as colorectal cancer. Combination therapy comprising infusional irinotencan, 5-fluorouracil (5-FU), with folinic acid (FOLFIRI) and bevacizumab is considered the first choice for metastatic colorectal cancer. Reports of TLS after therapy with FOLFIRI and bevacizumab are rare. Here...

article

Is peptic ulcer disease a risk factor of postherpetic neuralgia in patients with herpes zoster?

Jen-Yin Chen, Chia-Yu Chang, Kuo-Mao Lan, Ming-Jen Sheu, more

Medical Hypotheses > 2013 > 81 > 5 > 834-838

Postherpetic neuralgia is the most common complication of herpes zoster which is caused by a reactivation of latent varicella zoster virus. The pathogenesis of postherpetic neuralgia may involve peripheral and central mechanisms. Reported risk factors for postherpetic neuralgia include female gender, old age, diminished cell-mediated immunity and nutritional deficiencies. Based on our clinical observation...

article

Curcumin ameliorates methylglyoxal-induced alterations of cellular morphology and hyperpermeability in human umbilical vein endothelial cells

Te-Yu Hu, Cheng-Ling Liu, Jen-Yin Chen, Miao-Lin Hu

Journal of Functional Foods > 2013 > 5 > 2 > 745-754

Endothelial dysfunction such as hyperpermeability is one of the characteristics in an early stage of diabetic complications. Curcumin has been shown to inhibit the formation of advanced glycation end products (AGEs) and to trap methyglyoxal (MGO) in cell-free system and in human umbilical vein endothelial cells (HUVECs). Here, we investigated the effect of curcumin on dysfunctions of HUVECs induced...

article

Anti-angiogenic effects of lycopene through immunomodualtion of cytokine secretion in human peripheral blood mononuclear cells

Chin-Shiu Huang, Cheng-Hung Chuang, Tsue-Feng Lo, Miao-Lin Hu

The Journal of Nutritional Biochemistry > 2013 > 24 > 2 > 428-434

The carotenoid lycopene has been reported to possess anti-metastatic activity which may be associated with immunomodulation. However, the anti-angiogenic effects and mechanisms of action of lycopene have not been reported. In this study, we investigated the immunomodulatory effect on in vitro and ex vivo angiogenesis of lycopene. We found that the proliferation, migration and the matrigel tube formation...

article

Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway

Chih-Min Yang, Ya-Ling Lu, Huei-Yan Chen, Miao-Lin Hu

The Journal of Nutritional Biochemistry > 2012 > 23 > 9 > 1155-1162

In our previous study, we demonstrated that lycopene can inhibit the proliferation of androgen-dependent prostate LNCaP cancer cells through the activation of the peroxisome proliferator-activated receptor gamma (PPARγ)–liver X receptor alpha (LXRα)–ATP-binding cassette transporter 1 (ABCA1) pathway. However, it is still unclear whether lycopene possesses similar effects in androgen-independent prostate...

article

Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP‐2/uPA system through VEGFR2‐mediated PI3K‐Akt and ERK/p38 signaling pathways

Man‐Ling Chen, Yu‐Hsiu Lin, Chih‐Min Yang, Miao‐Lin Hu

Molecular Nutrition & Food Research > 56 > 6 > 889 - 899

ScopeLimited in vitro data show that lycopene may be anti‐angiogenic but with unclear mechanisms. Here, we employed ex vivo and in vivo assays to substantiate the anti‐angiogenic action of lycopene and determined its molecular mechanisms in human umbilical vein endothelial cells (HUVECs). Methods and resultsThe anti‐angiogenic activity of lycopene was confirmed by ex vivo rat aortic ring and in vivo...

article

Synergistic effects of the combination of β-ionone and sorafenib on metastasis of human hepatoma SK-Hep-1 cells

Chin-Shiu Huang, Shih-Chieh Lyu, Miao-Lin Hu

Investigational New Drugs > 2012 > 30 > 4 > 1449-1459

Summary The combination of anti-cancer drugs with nutritional factors is a potential strategy for improving the efficacy of chemotherapy, particularly for hepatocellular carcinoma because its conventional therapies are mostly ineffective. Using a highly invasive hepatoma SK-Hep-1 cell line, we investigated the possible synergistic anti-metastatic efficacy of a combination of sorafenib (SF), a multi-kinase...

article

Lycopene inhibits the proliferation of androgen-dependent human prostate tumor cells through activation of PPARγ-LXRα-ABCA1 pathway

Chih-Min Yang, I-Hsuan Lu, Huei-Yan Chen, Miao-Lin Hu

The Journal of Nutritional Biochemistry > 2012 > 23 > 1 > 8-17

The activation of nuclear receptors, peroxisome proliferator-activated receptor gamma (PPARγ) and liver X receptor alpha (LXRα), has been shown to inhibit the growth of prostate cancer cells. This study examined whether the anti-proliferative effect of lycopene on androgen-dependent human prostate cancer (LNCaP) cells involves the up-regulation of the expression of PPARγ and LXRα. As expected, lycopene...

article

S-Adenosylhomocysteine enhances DNA damage through increased β-amyloid formation and inhibition of the DNA-repair enzyme OGG1b in microglial BV-2 cells

Hung-Chi Lin, Tuzz-Ying Song, Miao-Lin Hu

Toxicology > 2011 > 290 > 2-3 > 342-349

S-Adenosylhomocysteine (SAH) is a risk factor for neurodegenerative diseases such as Alzheimer's disease, for which β-Amyliod (Aβ) formation is a major risk factor. We recently showed that SAH increases Aβ formation in mouse microglial BV2 cells. Here, we show that incubation of BV2 cells with SAH (0–500nM) for 6–24h sequentially increased Aβ formation, ROS and DNA damage measured as 8-oxo-deoxyguanosine...

article

Fucoxanthin Enhances HO-1 and NQO1 Expression in Murine Hepatic BNL CL.2 Cells through Activation of the Nrf2/ARE System Partially by Its Pro-oxidant Activity

Cheng-Ling Liu, Yu-Ting Chiu, Miao-Lin Hu

Journal of Agricultural and Food Chemistry > 2011 > 59 > 20 > 11344 - 11351

article

Protective effects of fucoxanthin against ferric nitrilotriacetate-induced oxidative stress in murine hepatic BNL CL.2 cells

Cheng-Ling Liu, Ai-Ling Liang, Miao-Lin Hu

Toxicology in Vitro > 2011 > 25 > 7 > 1314-1319

Fucoxanthin is a carotenoid that is rich in some seaweed. Although fucoxanthin has been reported to possess radical-scavenging activities in vitro, little is known whether it may protect against iron-induced oxidative stress in cultured cells. In this study, we examined the protection of fucoxanthin against oxidative damage in BNL CL.2 cells induced by ferric nitrilotriacetate (Fe-NTA). The data show...

article

Hispolon Induces Apoptosis and Cell Cycle Arrest of Human Hepatocellular Carcinoma Hep3B Cells by Modulating ERK Phosphorylation

Guan-Jhong Huang, Jeng-Shyan Deng, Shyh-Shyun Huang, Miao-Lin Hu

Journal of Agricultural and Food Chemistry > 2011 > 59 > 13 > 7104 - 7113

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Search results for: Miao-Lin Hu

Therapeutic treatment with ascorbate rescues mice from heat stroke-induced death by attenuating systemic inflammatory response and hypothalamic neuronal damage

The anti-angiogenic action of 2-deoxyglucose involves attenuation of VEGFR2 signaling and MMP-2 expression in HUVECs

Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice

Anti-metastatic effects of antrodan, the Antrodia cinnamomea mycelia glycoprotein, in lung carcinoma cells

A Nampt inhibitor FK866 mimics vitamin B₃ deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD⁺-SIRT1 signaling

Up-regulation of nicotinamide phosphoribosyltransferase and increase of NAD⁺ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells

Peptic ulcer as a risk factor for postherpetic neuralgia in adult patients with herpes zoster

Suppression of alpha-tocopherol ether-linked acetic acid in VEGF-induced angiogenesis and the possible mechanisms in human umbilical vein endothelial cells

Fatal tumor lysis syndrome in a patient with metastatic colon cancer after palliative chemotherapy

Is peptic ulcer disease a risk factor of postherpetic neuralgia in patients with herpes zoster?

Curcumin ameliorates methylglyoxal-induced alterations of cellular morphology and hyperpermeability in human umbilical vein endothelial cells

Anti-angiogenic effects of lycopene through immunomodualtion of cytokine secretion in human peripheral blood mononuclear cells

Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway

Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP‐2/uPA system through VEGFR2‐mediated PI3K‐Akt and ERK/p38 signaling pathways

Synergistic effects of the combination of β-ionone and sorafenib on metastasis of human hepatoma SK-Hep-1 cells

Lycopene inhibits the proliferation of androgen-dependent human prostate tumor cells through activation of PPARγ-LXRα-ABCA1 pathway

S-Adenosylhomocysteine enhances DNA damage through increased β-amyloid formation and inhibition of the DNA-repair enzyme OGG1b in microglial BV-2 cells

Fucoxanthin Enhances HO-1 and NQO1 Expression in Murine Hepatic BNL CL.2 Cells through Activation of the Nrf2/ARE System Partially by Its Pro-oxidant Activity

Protective effects of fucoxanthin against ferric nitrilotriacetate-induced oxidative stress in murine hepatic BNL CL.2 cells

Hispolon Induces Apoptosis and Cell Cycle Arrest of Human Hepatocellular Carcinoma Hep3B Cells by Modulating ERK Phosphorylation

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