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The reasons underlying the occurrence of multiple revertant genotypes in Wiskott–Aldrich syndrome (WAS) patients remain unclear. We have identified more than 30 revertant genotypes in a C995T WAS patient having 10–15% revertant, WAS protein (WASp)-expressing circulating lymphocytes [1]. Of 497 allospecific T-cell clones generated from the peripheral blood, 47.1% carried a revertant sequence. All revertant...
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