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The heterotrimeric G protein α q subunit (Gαq) mediates a variety of cell functions by activating the effector molecule phospholipase Cβ. Gαq activity is regulated by G protein βγ subunits, G protein-coupled receptors, RGS proteins, and Ric-8. In this study, we identified the lipid raft resident proteins, flotillin-1/reggie-2 and flotillin-2/reggie-1, as Gαq-binding proteins. The interactions of Gαq...
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