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Cutaneous squamous cell carcinoma (CSCC), which develops in response to ultraviolet irradiation exposure, is among the most common cancers. CSCC lesions can be removed by surgical excision, but 4.5% of these cancers reappear as aggressive and therapy‐resistant tumors. CSCC tumors display a high mutation burden, and tumor frequency is dramatically increased in immune‐suppressed patients, indicating...