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Zearalenone (ZEN) and its derivative, zearalanone (ZAN), are endocrine disruptive mycotoxins produced by Fusarium species. We investigated the human placental metabolism of ZEN and ZAN in vitro in JEG-3 cells, human term placental subcellular fractions and recombinant enzymes. Human placental enzymes were capable of metabolizing ZEN and ZAN to their primary OH-metabolites which have higher affinity...
The placenta regulates the passage of both endogenous and xenobiotic compounds to the fetus during pregnancy. A small number of xenobiotic metabolizing CYP enzymes are constantly expressed in placenta, those include CYP19A1 which mainly converts androgens to estrogens, and CYP1A1 whose substrates include steroid hormones and xenobiotics. We performed an analysis of co-expression of xenobiotic metabolizing...
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