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Hydrogen sulfide is considered as the third gasotransmitter, comparison with the two others (NO and CO) revealing similarities and differences. All three are in fact poisons as potent as cyanide because of the shared property to inhibit cellular respiration. However, in sharp contrast with the others H 2 S is also a mitochondrial substrate oxidized by mammalian cells if present below its toxic...
Sulfide shows the same toxicity as cyanide. This toxic effect results from the inhibition of the complex IV of the mitochondrial respiratory chain (cytochrome oxidase) that reduces oxygen into water. With the isolated enzyme the toxic effect is exerted in the high nanomolar range. However, significant inhibition of cellular/mitochondrial respiration needs μM concentrations (5–20μM). In contrast at...
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