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Human IgG subclass proteins exhibit more than 95% primary amino acid sequence homology in their Fc regions, but each has a unique profile for recognition by the 3 human Fcγ receptors. The FcγRs are themselves highly homologous members of the immunoglobulin supergene family. Consistent with these data we have proposed that FcγRI, FcγRII and FcγRIII recognise overlapping non-identical interaction sites...
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