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Chronic cerebral hypoperfusion leads to sustained demyelination and a unique response of microglia. Triggering receptor expressed on myeloid cells 2 (Trem2), which is expressed exclusively on microglia in the central nervous system (CNS), plays an essential role in microglial response in various CNS disorders. However, the specific role of Trem2 in chronic cerebral hypoperfusion has not been elucidated...
J. Neurochem. (2010) 113, 389–401.
AbstractAlzheimer’s disease (AD), a progressive neurodegenerative disease characterized by the accumulation of amyloid‐β protein and neuronal loss, is the leading cause of age‐related dementia in the world today. The disease is also associated with neuroinflammation, robust activation of astrocytes and microglia, and evidence of activation of the complement system,...
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