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Purpose We hypothesized that: (1) intraabdominal hypertension increases pulmonary inflammatory and fibrogenic responses in acute lung injury (ALI); (2) in the presence of intraabdominal hypertension, higher tidal volume reduces lung damage in extrapulmonary ALI, but not in pulmonary ALI. Methods Wistar rats were randomly allocated to receive Escherichia coli lipopolysaccharide intratracheally (pulmonary...
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