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One new lactone (1) named Ardisicreolide C, together with three saponin compounds, Ardisiacrispin B (2), Ardisicrenoside A (3), Ardisiacrispin A (4) were isolated and identified from the leaves of Ardisia crenata Sims. The structures of 1–4 were elucidated by 1D, 2D‐NMR and HR‐MS spectra and together with the published data. In view of structures with lactone moieties showed good anti‐inflammatory...