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Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Osteopontin (OPN), which is abundantly expressed in bone matrix, is involved in cell adhesion, migration, invasion and cell proliferation via interaction with its receptor, αvβ3 integrin. However, the effect of OPN on migration activity in human lung cancer cells is mostly unknown. Here...
Transforming growth factor-β1 (TGF-β1) plays a crucial role in adhesion and migration of human cancer cells. Besides, integrins are the major adhesive molecules in mammalian cells. Here we found that TGF-β1 increased the migration and cell surface expression of β1 integrin in human lung cancer cells (A549 cells). TGF-β1 stimulation increased phosphorylation of p85α subunit of phosphatidylinositol...
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