Search results for: Susumu Ito

Items from 1 to 20 out of 182 results

article

Psychogenic seizures in a child with infantile convulsions and choreoathetosis

Rina Shimomura, Susumu Ito, Naohiro Kurotaki, Kayoko Saito, more

Pediatrics International > 64 > 1 > n/a - n/a

article

An episode of acute encephalopathy with biphasic seizures and late reduced diffusion followed by hemiplegia and intractable epilepsy observed in a patient with a novel frameshift mutation in HNRNPU

Shino Shimada, Hirokazu Oguni, Yui Otani, Aiko Nishikawa, more

Brain and Development > 2018 > 40 > 9 > 813-818

Microdeletions in the 1q44 region encompassing the HNRNPU gene have been associated with infantile spasms and hemiconvulsion-hemiplegia-epilepsy syndrome. Recent studies have revealed that heterozygous HNRNPU variants resulted in early onset epilepsy and severe intellectual disability. A de novo frameshift mutation in HNRNPU was identified in a 5-year-old boy with developmental delay associated with...

article

Characterization and induction of phenolic acid decarboxylase from Aspergillus luchuensis

Mayumi Maeda, Masashi Tokashiki, Midori Tokashiki, Keiko Uechi, more

Journal of Bioscience and Bioengineering > 2018 > 126 > 2 > 162-168

Awamori is a traditional distilled liquor in the Ryukyu Islands, made from steamed rice by the action of the black-koji mold Aspergillus luchuensis and awamori yeast Saccharomyces cerevisiae. One of the specific flavors in aged awamori kusu is vanillin, which is derived from ferulic acid (FA) in rice grains. FA is released from the cell wall material in the rice grain by ferulic acid esterase produced...

article

Identification of novel SNORD118 mutations in seven patients with leukoencephalopathy with brain calcifications and cysts

Kazuhiro Iwama, Takeshi Mizuguchi, Jun‐ichi Takanashi, Hidehiro Shibayama, more

Clinical Genetics > 92 > 2 > 180 - 187

Background Leukoencephalopathy with brain calcifications and cysts (LCC) is neuroradiologically characterized by leukoencephalopathy, intracranial calcification, and cysts. Coats plus syndrome is also characterized by the same neuroradiological findings together with defects in retinal vascular development. Indeed, LCC and Coats plus were originally considered to be the same clinical entity termed...

article

Prevention of ventriculoperitoneal shunt complications after intraperitoneal urological surgeries

Takashi Ikeda, Sayaka Akiyama, Woo Jin Kim, Susumu Ito, more

Journal of Pediatric Surgery > 2017 > 52 > 7 > 1169-1172

To evaluate perioperative management for the prevention of postoperative shunt infection and malfunction after intraperitoneal urological surgery in patients with myelodysplasia and a ventriculoperitoneal shunt.From 2005 to 2015, 20 consecutive patients with myelodysplasia and a ventriculoperitoneal shunt who underwent intraperitoneal urological surgeries were managed with the same perioperative regimen...

chapter

Alkaline Enzymes in Current Detergency

Susumu Ito

Extremophiles Handbook > Extremophiles: Alkaliphiles > 229-251

article

EpCAM expression in breast cancer cells is associated with enhanced bone metastasis formation

Toru Hiraga, Susumu Ito, Hiroaki Nakamura

International Journal of Cancer > 138 > 7 > 1698 - 1708

Epithelial cell adhesion molecule (EpCAM) has been implicated in multiple cellular functions including cell adhesion. EpCAM has also recently been identified as a marker for cancer stem cells (CSCs). Here, we examined the roles of EpCAM in the development of bone metastasis of breast cancer by using well‐characterized animal models. Morphological and real‐time reverse transcriptase‐polymerase chain...

article

GABA and glycine in the developing brain

Susumu Ito

The Journal of Physiological Sciences > 2016 > 66 > 5 > 375-379

GABA and glycine are major inhibitory neurotransmitters in the CNS and act on receptors coupled to chloride channels. During early developmental periods, both GABA and glycine depolarize membrane potentials due to the relatively high intracellular Cl⁻ concentration. Therefore, they can act as excitatory neurotransmitters. GABA and glycine are involved in spontaneous neural network activities in the...

article

Identification and distribution of cellobiose 2-epimerase genes by a PCR-based metagenomic approach

Jun Wasaki, Hidenori Taguchi, Takeshi Senoura, Hiroshi Akasaka, more

Applied Microbiology and Biotechnology > 2015 > 99 > 10 > 4287-4295

Cellobiose 2-epimerase (CE) catalyzes the reversible epimerization of cellobiose to 4- O -β-d-glucopyranosyl-d-mannose. By using a PCR-based metagenomic approach, 71 ce -like gene fragments were obtained from wide-ranging environmental samples such as sheep rumen, soils, sugar beet extracts, and anaerobic sewage sludge. The frequency of isolation of the fragments similar...

article

The mannobiose-forming exo-mannanase involved in a new mannan catabolic pathway in Bacteroides fragilis

Kazuki Kawaguchi, Takeshi Senoura, Shigeaki Ito, Toki Taira, more

Archives of Microbiology > 2014 > 196 > 1 > 17-23

We have proposed a new mannan catabolic pathway in Bacteroides fragilis NCTC 9343 that involves a putative mannanase ManA in glycoside hydrolase family 26 (BF0771), a mannobiose and/or sugar transporter (BF0773), mannobiose 2-epimerase (BF0774), and mannosylglucose phosphorylase (BF0772). If this hypothesis is correct, ManA has to generate mannobiose from mannans as the major end product. In this...

article

Treatment outcomes and late toxicities in patients with embryonal central nervous system tumors

Kazumasa Odagiri, Motoko Omura, Masaharu Hata, Noriko Aida, more

Radiation Oncology > 2014 > 9 > 1 > 1-12

Background Standard treatment strategies for embryonal central nervous system (CNS) tumors have not yet been established. We treated these tumors using an original chemoradiation therapy protocol; the clinical outcomes and toxicities were retrospectively evaluated. Methods Twenty-four patients were enrolled including sixteen with medulloblastoma, four with supratentorial primitive neuroectodermal...

article

Structure of Novel Enzyme in Mannan Biodegradation Process 4-O-β-d-Mannosyl-d-Glucose Phosphorylase MGP

Setsu Nakae, Shigeaki Ito, Mariko Higa, Takeshi Senoura, more

Journal of Molecular Biology > 2013 > 425 > 22 > 4468-4478

The crystal structure of a novel component of the mannan biodegradation system, 4-O-β-d-mannosyl-d-glucose phosphorylase (MGP), was determined to a 1.68-Å resolution. The structure of the enzyme revealed a unique homohexameric structure, which was formed by using two helices attached to the N-terminus and C-terminus as a tab for sticking between subunits. The structures of MGP complexes with genuine...

article

Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment

Susumu Ito, Ikuo Ogiwara, Kazuyuki Yamada, Hiroyuki Miyamoto, more

Neurobiology of Disease > 2013 > 49 > Complete > 29-40

Dravet syndrome is an intractable epileptic encephalopathy characterized by early onset epileptic seizures followed by cognitive decline, hyperactivity, autistic behaviors and ataxia. Most Dravet syndrome patients possess heterozygous mutations of SCN1A gene encoding voltage-gated sodium channel α _I subunit (Na _v 1.1). We have previously reported that mice heterozygous for a nonsense...

article

Benign myoclonic epilepsy in infancy with preceding afebrile generalized tonic–clonic seizures in Japan

Susumu Ito, Hirokazu Oguni, Makiko Osawa

Brain and Development > 2012 > 34 > 10 > 829-833

Benign myoclonic epilepsy in infancy (BMEI) is the youngest form of idiopathic generalized epilepsy, characterized by myoclonic seizures (MS) in the first three years of life in otherwise normal infants, and the lack of other seizure types except for rare simple febrile seizures. Although afebrile generalized tonic–clonic seizures (GTCS) have been described to develop later in the clinical course...

article

Treatment Outcomes, Growth Height, and Neuroendocrine Functions in Patients With Intracranial Germ Cell Tumors Treated With Chemoradiation Therapy

Kazumasa Odagiri, Motoko Omura, Masaharu Hata, Noriko Aida, more

International Journal of Radiation Oncology, Biology, Physics > 2012 > 84 > 3 > 632-638

We carried out a retrospective review of patients receiving chemoradiation therapy (CRT) for intracranial germ cell tumor (GCT) using a lower dose than those previously reported. To identify an optimal GCT treatment strategy, we evaluated treatment outcomes, growth height, and neuroendocrine functions.Twenty-two patients with GCT, including 4 patients with nongerminomatous GCT (NGGCT) were treated...

article

Interconnections in superior temporal cortex revealed by musicogenic seizure propagation

Z. Irene Wang, Kazutaka Jin, Yosuke Kakisaka, Richard C. Burgess, more

Journal of Neurology > 2012 > 259 > 10 > 2251-2254

article

Purification and properties of phenolic acid decarboxylase from Candida guilliermondii

Hui-Kai Huang, Masamichi Tokashiki, Sayaka Maeno, Shoko Onaga, more

Journal of Industrial Microbiology & Biotechnology > 2012 > 39 > 1 > 55-62

A heat-labile phenolic acid decarboxylase from Candida guilliermondii (an anamorph of Pichia guilliermondii) was purified to homogeneity by simple successive column chromatography within 3 days. The molecular mass was 20 kDa by sodium dodecyl sulfate–polyacrylamide gel electrophoresis and 36 kDa by gel-filtration chromatography, suggesting that the purified enzyme is a homodimer. The optimal pH and...

article

Thy-1-positive cells in the subodontoblastic layer possess high potential to differentiate into hard tissue-forming cells

Akihiro Hosoya, Toru Hiraga, Tadashi Ninomiya, Akira Yukita, more

Histochemistry and Cell Biology > 2012 > 137 > 6 > 733-742

The cells of the subodontoblastic cell-rich layer in dental pulp are speculated to contain odontoblast progenitor cells because of their positional relationship with odontoblasts as well as their high alkaline phosphatase (ALP) activity. However, it has yet to be determined whether these cells have the ability to differentiate into odontoblastic cells. In the present study, we firstly found that the...

article

An endogenous factor enhances ferulic acid decarboxylation catalyzed by phenolic acid decarboxylase from Candida guilliermondii

Hui-Kai Huang, Li-Fan Chen, Masamichi Tokashiki, Tadahiro Ozawa, more

AMB Express > 2012 > 2 > 1 > 1-10

The gene for a eukaryotic phenolic acid decarboxylase of Candida guilliermondii was cloned, sequenced, and expressed in Escherichia coli for the first time. The structural gene contained an open reading frame of 504 bp, corresponding to 168 amino acids with a calculated molecular mass of 19,828 Da. The deduced amino sequence exhibited low similarity to those of functional phenolic acid decarboxylases...

article

Novel nonsecosteroidal vitamin D3 carboxylic acid analogs for osteoporosis, and SAR analysis

Hirotaka Kashiwagi, Yoshiyuki Ono, Kazuki Shimizu, Tsuyoshi Haneishi, more

Bioorganic & Medicinal Chemistry > 2011 > 19 > 16 > 4721-4729

Novel vitamin D ₃ analogs with carboxylic acid were explored, focusing on a nonsecosteroidal analog, LG190178, with a bisphenyl skeleton. From X-ray analysis of these analogs with vitamin D receptor (VDR), the carboxyl groups had very unique hydrogen bonding interactions in VDR and mimicked 1α-hydroxy group and/or 3β-hydroxy group of 1α,25-dihydroxyvitamin D ₃ . A highly potent analog,...

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INFONA - science communication portal

Search results for: Susumu Ito

Psychogenic seizures in a child with infantile convulsions and choreoathetosis

An episode of acute encephalopathy with biphasic seizures and late reduced diffusion followed by hemiplegia and intractable epilepsy observed in a patient with a novel frameshift mutation in HNRNPU

Characterization and induction of phenolic acid decarboxylase from Aspergillus luchuensis

Identification of novel SNORD118 mutations in seven patients with leukoencephalopathy with brain calcifications and cysts

Prevention of ventriculoperitoneal shunt complications after intraperitoneal urological surgeries

Alkaline Enzymes in Current Detergency

EpCAM expression in breast cancer cells is associated with enhanced bone metastasis formation

GABA and glycine in the developing brain

Identification and distribution of cellobiose 2-epimerase genes by a PCR-based metagenomic approach

The mannobiose-forming exo-mannanase involved in a new mannan catabolic pathway in Bacteroides fragilis

Treatment outcomes and late toxicities in patients with embryonal central nervous system tumors

Structure of Novel Enzyme in Mannan Biodegradation Process 4-O-β-d-Mannosyl-d-Glucose Phosphorylase MGP

Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment

Benign myoclonic epilepsy in infancy with preceding afebrile generalized tonic–clonic seizures in Japan

Treatment Outcomes, Growth Height, and Neuroendocrine Functions in Patients With Intracranial Germ Cell Tumors Treated With Chemoradiation Therapy

Interconnections in superior temporal cortex revealed by musicogenic seizure propagation

Purification and properties of phenolic acid decarboxylase from Candida guilliermondii

Thy-1-positive cells in the subodontoblastic layer possess high potential to differentiate into hard tissue-forming cells

An endogenous factor enhances ferulic acid decarboxylation catalyzed by phenolic acid decarboxylase from Candida guilliermondii

Novel nonsecosteroidal vitamin D3 carboxylic acid analogs for osteoporosis, and SAR analysis

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