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Among the costimulatory factors widely studied in the immune system is the CD28/cytotoxic T‐lymphocyte antigen‐4 (CTLA4)‐CD80/CD86 pathway, which critically controls the nature and duration of the T‐cell response. In the brain, up‐regulated expression of CD80/CD86 during inflammation has consistently been reported in microglia. However, the role of CD80/CD86 molecules has mainly been studied in a...
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