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Chronic inflammatory microenvironment is the predominant milieu that promotes the progression of atherosclerosis (AS). However, targeted regulation of the chronic proinflammatory milieu still needs to be improved. In this study, macrophage‐targeting nanosystems composed of 37pA peptide embedded–Pt lipid nanoparticles (37pA‐PtLNP) and tumor necrosis factor‐associated factor 6 (TRAF6) inhibitor (6877002)‐loaded...
“Gemini” Nanosystems
In article number 2301053, Huile Gao, Jinrong Peng, Qian Yang, and co‐workers developed “Gemini” nanosystems to regulate the atherosclerotic plaque microenvironment, in which the platinum‐based nanosystem effectively scavenges intracellular reactive oxygen species of inflammatory macrophage, and the TRAF6 small molecule inhibitor nanosystem modulates inflammatory immune response...