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A multi-layer coating enabled drug delivery method has been developed here to augment AFM based nanorobot technology. Being developed for over a decade, the AFM based nanorobot has been established as a key concept of nanorobotics, and has been applied in nanomaterial and biomedical related research. In these AFM based nanorobots, however, the AFM tip was mainly used as a mechanical end-effector to...
Cell tensegrity model has been widely accepted as a qualitative and recently quantitative method to describe the cellular mechanics. It is based on the fact the cell body is an inhomogeneous cytoskeleton based structure bounded by a soft membrane. Cell establishes force balance under certain structural arrangement through its focal adhesions and intercellular adhesions, under which the prestress is...
This paper presents a new and reliable approach for in-situ imaging and manipulation of membrane protein molecules. The major problematic issue in medicine is the lack of fundamental understanding of the molecular mechanisms that cause major life-threatening and incurable diseases. The development of atomic force microscopy (AFM) opens an entirely new way to address these medical questions. A biocompatible...
We report the use of Atomic Force Microcopy (AFM) in combination with Fluorescence Microscopy (FM) for the investigation of non-Hodgkin's type B cells lymphoma after antibody treatment. Rituximab is used in the treatment this cancer type. It is a chimeric monoclonal antibody directed against the protein Cluster of Differentiation 20 (CD20), which is expressed on mature B cells, including the B cell...
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