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We present the use of atomic force microscopy (AFM) to visualize and quantify the dynamics of epithelial cell junction interactions under physiological and pathophysiological conditions at the nanoscale. Desmosomal junctions are critical cellular adhesion components within epithelial tissues and blistering skin diseases such as Pemphigus are the result in the disruption of these components. However,...
Cell tensegrity model has been widely accepted as a qualitative and recently quantitative method to describe the cellular mechanics. It is based on the fact the cell body is an inhomogeneous cytoskeleton based structure bounded by a soft membrane. Cell establishes force balance under certain structural arrangement through its focal adhesions and intercellular adhesions, under which the prestress is...
This paper presents a new and reliable approach for in-situ imaging and manipulation of membrane protein molecules. The major problematic issue in medicine is the lack of fundamental understanding of the molecular mechanisms that cause major life-threatening and incurable diseases. The development of atomic force microscopy (AFM) opens an entirely new way to address these medical questions. A biocompatible...
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