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After cardiac transplantation, pts benefit from pravastatin, but the chance of side-effects may be increased due to drug interaction between statine and cyclosporine. We treated 50 long-term heart transplant survivors (44 males, 6 females, mean age 52.3 + 11.3 yrs, time after transplant 60.8 +- 38.2 months) with pravastatin (5 mg in 1.10 mg in 20.20 mg in 24, and 40 mg in 1 pts). After 12 months...
Hyperlipidemia is a common problem following organ transplantation and may contribute to transplant coronary artery disease. During treatment with HMG-CoA-reductase inhibitors and cyclosporine, however, side effects like rhabdomyolysis occured in some cases. The purpose of this study was to proof the safety and the efficacy of the treatment with the hydrophylic HMG-CoA-reductase inhibitor pravastatin...
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