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A photo‐cross‐linked micelle is synthesized via photodimerization of thymine moieties fabricated from amphiphilic block copolymers (mPEG‐b‐P(LA‐co‐MPT). The crosslinking behavior is monitored by UV‐Vis spectra and 1H NMR. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) showed that cross‐linked micelles had smaller sizes than their uncross‐linked precursors. In vitro studies...
A core cross‐linked polymeric micellar cisplatin(IV) conjugate prodrug is prepared by attaching the cisplatin(IV) to mPEG‐b‐PLL biodegradable copolymers to form micellar nanoparticles that can disintegrate to release the active anticancer agent cisplatin(II) in a mild reducing environment. Moreover, in vitro studies show that this cisplatin(IV) conjugate prodrug displays enhanced cytotoxicity against...
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