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We performed a genome‐wide linkage analysis to identify susceptibility loci in a large six‐generation extended family previously reported with early‐onset osteoarthritis (OA) DNA sequencing was performed to investigate involvement of the COMP (Cartilage oligomeric matrix protein) gene in this family. The region covering D19S884, D19S226, and D19S414 on chromosome 19p following genome‐wide scan from...
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