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Background Pirfenidone was recently approved for treatment of idiopathic pulmonary fibrosis. However, the therapeutic dose of pirfenidone is very high, causing side effects that limit its doses and therapeutic effectiveness. Understanding the molecular mechanisms of action of pirfenidone could improve its safety and efficacy. Because activated fibroblasts are critical effector cells associated with...
G‐protein‐coupled receptor (GPCR)‐stimulated androgen‐independent activation of androgen receptor (AR) contributes to acquisition of a hormone‐refractory phenotype by prostate cancer. We previously reported that regulator of G‐protein signaling (RGS) 2, an inhibitor of GPCRs, inhibits androgen‐independent AR activation (Cao et al., Oncogene 2006;25:3719‐34). Here, we show reduced RGS2 protein expression...
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