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TNF‐α has long been implicated in the progression of rheumatoid arthritis (RA). However, how the receptors of TNF‐α, namely TNFR1 and TNFR2, mediate TNF‐α‐induced inflammatory responses in fibroblast‐like synoviocytes (FLS) in RA has not been elucidated. In the present study, primary FLS cells were isolated from RA patients and treated with TNF‐α in vitro. The exogenous TNF‐α induced the expression...
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