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The catalytic motif (YSASK) at the active site of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is conserved across different species. The crystal structures of the human, guinea pig and mouse enzymes have been resolved to help identify the non-conserved residues at the active site. A tyrosine residue (Y177) upstream of the catalytic motif in human 11β-HSD1 represents the largest difference at...
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