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Fresh human endometrial explants were incubated for 24h at 37 o C with either tamoxifen (10-100μM) or the vehicle (0.1% ethanol). Three metabolites namely, α-hydroxytamoxifen, 4-hydroxytamoxifen, and N-desmethyltamoxifen were identified in the culture media. Tissue size was limited but DNA adducts formed by the α-hydroxytamoxifen pathway were detected using authentic α-(deoxyguanosyl-N ...
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